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16357-59-8 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ)

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CAS： 16357-59-8 MDL Number： MFCD00006703 MF： C14H17NO3 MW： 247.29 Purity： 97+% Product Description： Relevant Medicine Name： - COA SDS

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Reagent for peptide coupling. Reaction proceeds via the anhydride of the acid component: J. Am. Chem. Soc., 90, 823, 1651 (1968); Int. J. Pept. Prot. Res., 26, 493 (1985).
For activation of ɑ -hydroxy acids, see: Tetrahedron Lett, 40, 3435 (1999) . Also used for the mild esterification of alcohols, e.g. for introduction of the levulinate protecting group: Tetrahedron Lett., 23, 2615 (1982). For a useful esterification technique applicable to primary, secondary and tertiary alcohols, see: J. Org. Chem., 60, 7072 (1995).