147-85-3 L-(-)-Proline

Flash point
Boiling point	252.2℃ at 760 mmHg
Density	1.360(lit.)
Storage	Inert atmosphere/Light & Moisture sensitive

For use as a catalyst in an asymmetric aldol cyclization, see: Org. Synth. Coll., 7, 363 (1990). For use in a direct enantioselective crossed aldol reaction with aldehydes, see: J. Am. Chem. Soc., 124, 6798 (2002). For use as an organoctalyst in direct aldol reactions of ɑ-oxyaldehydes, as the first step in a two-step synthesis of carbohydrates, see: Angew. Chem. Int. Ed., 43, 2152 (2004). Mediates the enantioselective borane reduction of ketones to chiral alcohols with moderate to good ee: Monatsh. Chem., 131, 91 (2000). Also used to induce high ee in the ɑ-amination of aldehydes with Dibenzyl- azodicarboxyl-ate: J. Am. Chem. Soc., 124, 5656 (2002), or Diethyl- azodicarboxyl-ate: Angew. Chem. Int. Ed., 41, 1790 (2002).
For a review of the use of proline as a chiral catalyst, see: Synlett, 1675 (2001); Synlett, 1973 (2006).