Regioselective metallation can be accomplished with LDA ortho to the fluoro substituent: Tetrahedron Lett., 33, 7499 (1992). Subsequent carboxylation and F - displacement with an amine has been used to synthesize 5-iodoanthranilic acid derivatives: J. Med. Chem., 40, 717 (1997).
Copyrights 2018 Accela ChemBio Inc. All Rights Reserved Hot Cas | Cas
9883 Pacific Heights Blvd., Suite H, San Diego, CA 92121 Tel: (858) 699-3322 Fax: (858) 876-1948 Inquiry/Orders: email@example.comSales management