6163-58-2 Tri(o-tolyl)phosphine
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Preferred phosphine ligand for use in combination with Pd salts in the Heck-type coupling reactions of vinylic halides. For examples, see Palladium(II)- acetate. For a review of the Heck reaction, see: Org. React., 27, 345 (1982). The Pd-catalyzed amination of bromoarenes with 1-Boc-piperazine, in the presence of this ligand, provides a route to arylpiperazines of potential pharmacological interest: Tetrahedron Lett., 39, 2219 (1998).
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